PF3D7_1215700

Genome location: Pf3D7_12_v3:635,538..638,879(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.00	1.00
Gametocyte	possibly expressed	0.40	0.82

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1215700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.343 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1431400)

Modification: Disrupted | RMgm-3896

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5Q0

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.25) with 3MMR (Global RMSD=49.67)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532928

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	53	29	76
disruptive	49	264	124	260
missense	37	244	116	230

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	12	106	49	103
disruptive	106	470	197	355
missense	73	414	171	281

PlasmoDB Total SNPs: 116

Non-coding: 0 | Synonymous: 57 | Nonsynonymous: 56 | Stop Codon: 3

Protein Information

Protein Length: 1113 | Molecular Weight (kDa): 130.678

UniProt ID(s): Q8I5Q0

PDB ID(s): None

Isoelectric Point: 7.2

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A