Product Description: radial spoke protein 9, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005930 | axoneme |
| Process | GO:0035082 | axoneme assembly |
| Process | GO:0060294 | cilium movement involved in cell motility |
| Process | GO:0044458 | motile cilium assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | not expressed | 0.00 | 1.00 |
| Schizont | not expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.29 | 0.86 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1215800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.259 | MFS: -2.335 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1431500)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1431500)
Modification: Mutated | RMgm-5379
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104080
Most Similar Human Ortholog: Q9H1X1
TM-align score: 0.84 | RMSD: 2.62
Seq Identity: 0.26 | Length: 254 / 366
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000172426 | radial spoke head component 9 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 21 | 13 | 25 |
| disruptive | 23 | 60 | 46 | 102 |
| missense | 13 | 48 | 33 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 45 | 14 | 28 |
| disruptive | 42 | 151 | 63 | 147 |
| missense | 22 | 107 | 45 | 88 |
PlasmoDB Total SNPs: 46
Non-coding: 0 | Synonymous: 35 | Nonsynonymous: 10 | Stop Codon: 1
Protein Length: 366 | Molecular Weight (kDa): 43.643
UniProt ID(s): Q8I5P9
PDB ID(s): None
Isoelectric Point: 4.34
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 37288670 | Radial spoke protein 9 is necessary for axoneme assembly in Plasmodium but not intrypanosomatid parasites | Ramakrishnan C, Fort C, ..., Sinden RE | 10.1242/jcs.260655 |