Product Description: serpentine receptor 10
SignalP Peptide: N/A
# Transmembrane Domains: 8
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005794 | Golgi apparatus |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0005515 | protein binding |
| Process | GO:0006260 | DNA replication |
| Process | GO:0044114 | development of symbiont in host |
| Process | GO:0042752 | regulation of circadian rhythm |
| Process | GO:0006511 | ubiquitin-dependent protein catabolic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.38 | 0.82 |
| Trophozoite | possibly expressed | 0.90 | 0.52 |
| Schizont | not expressed | 0.38 | 0.77 |
| Gametocyte | not expressed | 0.49 | 0.72 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1215900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.992 | MFS: -2.996 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1431600)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PCHAS_1433600)
Modification: Disrupted | RMgm-4839
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P8
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101701
Most Similar Human Ortholog: Q96K49
TM-align score: 0.61 | RMSD: 4.58
Seq Identity: 0.19 | Length: 404 / 655
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000103978 | transmembrane protein 87A |
| ENSG00000153214 | transmembrane protein 87B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 34 | 15 | 35 |
| disruptive | 39 | 63 | 35 | 95 |
| missense | 14 | 48 | 30 | 68 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 67 | 29 | 40 |
| disruptive | 57 | 169 | 70 | 174 |
| missense | 20 | 115 | 52 | 99 |
PlasmoDB Total SNPs: 85
Non-coding: 30 | Synonymous: 29 | Nonsynonymous: 25 | Stop Codon: 1
Protein Length: 655 | Molecular Weight (kDa): 76.857
UniProt ID(s): Q8I5P8
PDB ID(s): None
Isoelectric Point: 6.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR009637 | Transmembrane protein GPR107/GPR108-like |
| PFam | PF06814 | Transmembrane protein GPR107/GPR108-like |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 32488076 | Malaria parasites regulate intra-erythrocytic development duration via serpentinereceptor 10 to coordinate with host rhythms. | Subudhi AK, O'Donnell AJ, ..., Pain A | 10.1038/s41467-020-16593-y |
| 32890576 | The endoplasmic reticulum-resident serpentine receptor SR10 has importantfunctions for asexual and sexual blood stage development of Plasmodiumfalciparum. | Njila Tchoufack EJ, Hahnfeld L, ..., Pradel G | 10.1016/j.molbiopara.2020.111315 |
| 30364017 | Purinergic Antagonist Suramin Aggravates Myocarditis and Increases Mortality byEnhancing Parasitism, Inflammation, and Reactive Tissue Damage in Trypanosomacruzi-Infected Mice | Novaes RD, Santos EC, ..., Oliveira LL | 10.1155/2018/7385639 |