Product Description: signal recognition particle subunit SRP19
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 3.6.5.4 (Signal-recognition-particle GTPase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0005789 | endoplasmic reticulum membrane |
| Component | GO:0005634 | nucleus |
| Component | GO:0005786 | signal recognition particle, endoplasmic reticulum targeting |
| Function | GO:0008312 | 7S RNA binding |
| Function | GO:0005515 | protein binding |
| Function | GO:0043022 | ribosome binding |
| Process | GO:0006617 | SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.61 | 0.71 |
| Trophozoite | possibly expressed | 0.46 | 0.72 |
| Schizont | expressed | 0.25 | 0.83 |
| Gametocyte | not expressed | 0.42 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1216300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.129 | MFS: -3.394 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1432000)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P4
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 3.6.5.4 | signal-recognition-particle GTPase | GDPsignal peptideLamB signal peptide |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101284
Most Similar Human Ortholog: A0A2R8Y4M3
TM-align score: 0.79 | RMSD: 1.82
Seq Identity: 0.34 | Length: 68 / 152
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000153037 | signal recognition particle 19 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 1 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 95
Non-coding: 85 | Synonymous: 8 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 152 | Molecular Weight (kDa): 18.025
PDB ID(s): None
Isoelectric Point: 10.31
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002778 | Signal recognition particle, SRP19 subunit |
| InterPro | IPR036521 | Signal recognition particle, subunit SRP19-like superfamily |
| PFam | PF01922 | Signal recognition particle, SRP19 subunit |
| Superfamily | SSF69695 | Signal recognition particle, subunit SRP19-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17919451 | Unraveling the components of protein translocation pathway in human malariaparasite Plasmodium falciparum. | Tuteja R | 10.1016/j.abb.2007.08.031 |
| 24434517 | Plasmodium falciparum signal recognition particle components and anti-parasiticeffect of ivermectin in blocking nucleo-cytoplasmic shuttling of SRP. | Panchal M, Rawat K, ..., Tuteja R | 10.1038/cddis.2013.521 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |