About Gene List

PF3D7_1216400

Genome location: Pf3D7_12_v3:653,412..656,584(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 9

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 0.78 0.64
Trophozoite expressed 0.67 0.62
Schizont expressed 0.54 0.68
Gametocyte expressed 0.80 0.57

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1216400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.672 | MFS: -2.907 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5P3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_136565

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 42 21 51
disruptive 50 132 71 163
missense 28 116 65 148

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 12 87 38 54
disruptive 79 258 116 226
missense 44 214 106 163

PlasmoDB Total SNPs: 169

Non-coding: 65 | Synonymous: 50 | Nonsynonymous: 54 | Stop Codon: 0

Protein Information

Protein Length: 921 | Molecular Weight (kDa): 109.126

UniProt ID(s): Q8I5P3

PDB ID(s): None

Isoelectric Point: 8.85

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104