Product Description: male development gene 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0044310 | osmiophilic body |
| Component | GO:0005886 | plasma membrane |
| Component | GO:0020005 | symbiont-containing vacuole membrane |
| Component | GO:0005774 | vacuolar membrane |
| Process | GO:0035891 | exit from host cell |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.17 | 0.90 |
| Schizont | expressed | 0.24 | 0.85 |
| Gametocyte | expressed | 3.12 | 0.15 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1216500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 1.33 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1432200)
Modification: Tagged | RMgm-1480
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 13 | 3 | 9 |
| disruptive | 8 | 11 | 13 | 27 |
| missense | 8 | 11 | 13 | 27 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 18 | 8 | 15 |
| disruptive | 9 | 30 | 25 | 51 |
| missense | 9 | 27 | 23 | 42 |
PlasmoDB Total SNPs: 132
Non-coding: 110 | Synonymous: 10 | Nonsynonymous: 11 | Stop Codon: 1
Protein Length: 221 | Molecular Weight (kDa): 25.757
UniProt ID(s): Q8I5P2
PDB ID(s): None
Isoelectric Point: 4.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16275909 | Disruption of a Plasmodium falciparum gene linked to male sexual developmentcauses early arrest in gametocytogenesis. | Furuya T, Mu J, ..., Su XZ | 10.1073/pnas.0501858102 |
| 17367781 | Plasmodium falciparum: mRNA co-expression and protein co-localisation of two geneproducts upregulated in early gametocytes. | Lanfrancotti A, Bertuccini L, Silvestrini F, Alano P | 10.1016/j.exppara.2007.01.021 |
| 19438517 | Egress of Plasmodium berghei gametes from their host erythrocyte is mediated bythe MDV-1/PEG3 protein. | Ponzi M, Siden-Kiamos I, ..., Alano P | 10.1111/j.1462-5822.2009.01331.x |
| 37492994 | Comparative proteomics of vesicles essential for the egress of Plasmodiumfalciparum gametocytes from red blood cells | Sassmannshausen J, Bennink S, ..., Pradel G | 10.1111/mmi.15125 |