Product Description: cell traversal protein for ookinetes and sporozoites
SignalP Peptide: MNALRRLPVICSFLVFLVFSNVLC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020009 | microneme |
| Function | GO:0005515 | protein binding |
| Process | GO:0071976 | cell gliding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | not expressed | 0.08 | 0.96 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.04 | 0.98 |
| Gametocyte | expressed | 0.29 | 0.83 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1216600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.123 | MFS: -2.887 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1432300)
Modification: Tagged | RMgm-4558
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5P1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 4 | 3 | 14 |
| disruptive | 43 | 12 | 8 | 18 |
| missense | 43 | 12 | 7 | 16 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 15 | 6 | 11 |
| disruptive | 48 | 22 | 13 | 23 |
| missense | 47 | 18 | 12 | 22 |
PlasmoDB Total SNPs: 35
Non-coding: 0 | Synonymous: 1 | Nonsynonymous: 34 | Stop Codon: 0
Protein Length: 182 | Molecular Weight (kDa): 20.139
UniProt ID(s): A0A2R4QLA5, A0A2R4QLI0, A0A2R4QLI5, A0A2R4QLJ1, A0A2R4QLJ4, M1ETJ8, Q53UB8, Q8I5P1
Isoelectric Point: 4.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR041004 | Cell-traversal protein for ookinetes and sporozoites |
| PFam | PF18659 | Cell-traversal protein for ookinetes and sporozoites |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16468982 | CelTOS, a novel malarial protein that mediates transmission to mosquito andvertebrate hosts. | Kariu T, Ishino T, ..., Yuda M | 10.1111/j.1365-2958.2005.05024.x |
| 29253313 | Plasmodium yoelii S4/ CelTOS is important for sporozoite gliding motility and celltraversal | Steel RWJ, Pei Y, ..., Kappe SHI | 10.1111/cmi.12817 |
| 33515807 | Systematic Identification of Plasmodium Falciparum Sporozoite Membrane ProteinInteractions Reveals an Essential Role for the p24 Complex in Host Infection. | Knockel J, Dundas K, ..., Wright GJ | 10.1074/mcp.RA120.002432 |
| 30543766 | Heterogeneity in the acquisition of naturally acquired antibodies tocell-traversal protein for ookinetes and sporozoites (CelTOS) andthrombospondin-related adhesion protein (TRAP) of Plasmodium falciparum innaturally infected patients from unstable malaria areas in Iran | Pirahmadi S, Zakeri S, ..., Djadid ND | 10.1016/j.actatropica.2018.12.014 |
| 36726645 | Naturally acquired antibodies to gametocyte antigens are associated with reducedtransmission of Plasmodium vivax gametocytes to Anopheles arabiensis mosquitoes | Tebeje SK, Chali W, ..., Bousema T | 10.3389/fcimb.2022.1106369 |
| 29391203 | Analysis of genetic diversity and population structure of gene encodingcell-traversal protein for ookinetes and sporozoites (CelTOS) vaccine candidateantigen in global Plasmodium falciparum populations | Pirahmadi S, Zakeri S, Mehrizi AA, Djadid ND | 10.1016/j.meegid.2018.01.023 |
| 32266169 | Plasmodium vivax Cell Traversal Protein for Ookinetes and Sporozoites (CelTOS)Functionally Restricted Regions Are Involved in Specific Host-PathogenInteractions | Arevalo-Pinzon G, Garzon-Ospina D, ..., Patarroyo MA | 10.3389/fcimb.2020.00119 |
| 37624318 | In Silico Analysis Reveals High Levels of Genetic Diversity of Plasmodiumknowlesi Cell Traversal Protein for Ookinetes and Sporozoites (PkCelTOS) inClinical Samples | Ahmed MA, Baruah P, ..., Quan FS | 10.3390/tropicalmed8080380 |
| 30506260 | Expression of Recombinant PfCelTOS Antigen in the Chloroplast of Chlamydomonasreinhardtii and its Potential Use in Detection of Malaria | Shamriz S, Ofoghi H | 10.1007/s12033-018-0140-1 |
| 30936155 | Combining Monophosphoryl Lipid A (MPL), CpG Oligodeoxynucleotide (ODN), and QS-21Adjuvants Induces Strong and Persistent Functional Antibodies and T CellResponses against Cell-Traversal Protein for Ookinetes and Sporozoites (CelTOS)of Plasmodium falciparum in BALB/c Mice | Pirahmadi S, Zakeri S, ..., Sani JJ | 10.1128/IAI.00911-18 |
| 34415964 | IMRAS-Immunization with radiation-attenuated Plasmodium falciparum sporozoites bymosquito bite: Cellular immunity to sporozoites, CSP, AMA1, TRAP and CelTOS | Sedegah M, Hollingdale MR, ..., Villasante E | 10.1371/journal.pone.0256396 |
| 36591298 | Exploring in vitro expression and immune potency in mice using mRNA encoding thePlasmodium falciparum malaria antigen, CelTOS | Waghela IN, Mallory KL, ..., Angov E | 10.3389/fimmu.2022.1026052 |
| 35809642 | Implications of conformational flexibility, lipid binding, and regulatory domainsin cell-traversal protein CelTOS for apicomplexan migration | Kumar H, Jimah JR, ..., Tolia NH | 10.1016/j.jbc.2022.102241 |
| 35697572 | Norovirus-VLPs expressing pre-erythrocytic malaria antigens induce functionalimmunity against sporozoite infection | Schneider CG, Fey J, ..., Angov E | 10.1016/j.vaccine.2022.05.076 |
| 38030029 | Plasmodium falciparum population structure and genetic diversity of celltraversal protein for ookinetes and sporozoites (CelTOS) during malariaresurgences in Dielmo, Senegal | Wotodjo AN, Oboh MA, ..., D'Alessandro U | 10.1016/j.meegid.2023.105535 |
| 34376744 | In silico characterisation of putative Plasmodium falciparum vaccine candidatesin African malaria populations | Ajibola O, Diop MF, ..., Amambua-Ngwa A | 10.1038/s41598-021-95442-4 |
| 31014347 | Cell-traversal protein for ookinetes and sporozoites (CelTOS) formulated withpotent TLR adjuvants induces high-affinity antibodies that inhibit Plasmodiumfalciparum infection in Anopheles stephensi | Pirahmadi S, Zakeri S, ..., Ghorbanzadeh Z | 10.1186/s12936-019-2773-3 |
| 36642628 | Immunodominant T cell peptides from four candidate malarial antigens asbiomarkers of protective immunity against malaria | Belmonte M, Ganeshan H, ..., Sedegah M | 10.1016/j.vaccine.2023.01.016 |
| 34969544 | Towards large-scale identification of HLA-restricted T cell epitopes from fourvaccine candidate antigens in a malaria endemic community in Ghana | Kusi KA, Ofori EA, ..., Sedegah M | 10.1016/j.vaccine.2021.12.042 |
| 38218737 | Naturally acquired antibodies against Plasmodium vivax pre-erythrocytic stagevaccine antigens inhibit sporozoite invasion of human hepatocytes in vitro | Ntumngia FB, Kolli SK, ..., Adams JH | 10.1038/s41598-024-51820-2 |
| 36182066 | Population genetic analysis of Plasmodium falciparum cell-traversal protein forookinetes and sporozoite among malaria patients from southern Nigeria | Oboh MA, Isaac C, ..., Thomas BN | 10.1016/j.meegid.2022.105369 |
| 35108259 | Global diversity and balancing selection of 23 leading Plasmodium falciparumcandidate vaccine antigens | Naung MT, Martin E, ..., Barry AE | 10.1371/journal.pcbi.1009801 |
| 31630257 | Codon harmonization reduces amino acid misincorporation in bacterially expressedP. falciparum proteins and improves their immunogenicity | Punde N, Kooken J, ..., Angov E | 10.1186/s13568-019-0890-6 |