Product Description: DNA-binding chaperone, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | expressed | N/A | N/A |
Ring | expressed | 1.56 | 0.36 |
Trophozoite | expressed | 1.73 | 0.26 |
Schizont | expressed | 0.57 | 0.70 |
Gametocyte | expressed | 1.11 | 0.45 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1216900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.137 | MFS: -2.85 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1432500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5N9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102149
Most Similar Human Ortholog: C9IZ83
TM-align score: 0.82 | RMSD: 2.58
Seq Identity: 0.40 | Length: 176 / 939
All Human Orthologs (OrthoMCL):
Gene ID | Description |
---|---|
ENSG00000105821 | DnaJ heat shock protein family (Hsp40) member C2 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 7 | 54 | 29 | 71 |
disruptive | 33 | 105 | 72 | 138 |
missense | 20 | 91 | 65 | 111 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 17 | 119 | 40 | 68 |
disruptive | 60 | 255 | 130 | 270 |
missense | 36 | 203 | 100 | 169 |
PlasmoDB Total SNPs: 428
Non-coding: 330 | Synonymous: 54 | Nonsynonymous: 44 | Stop Codon: 0
Protein Length: 939 | Molecular Weight (kDa): 111.065
UniProt ID(s): Q8I5N9
PDB ID(s): None
Isoelectric Point: 8.96
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR001005 | SANT/Myb domain |
InterPro | IPR001623 | DnaJ domain |
InterPro | IPR009057 | Homeobox-like domain superfamily |
InterPro | IPR036869 | Chaperone J-domain superfamily |
PFam | PF00226 | DnaJ domain |
Superfamily | SSF46565 | Chaperone J-domain superfamily |
Superfamily | SSF46689 | Homeobox-like domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |