About Gene List

PF3D7_1216900

Genome location: Pf3D7_12_v3:668,256..674,672(+)

Genome classification: Core

Function and Localization

Product Description: DNA-binding chaperone, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring expressed 1.56 0.36
Trophozoite expressed 1.73 0.26
Schizont expressed 0.57 0.70
Gametocyte expressed 1.11 0.45

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1216900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.85 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1432500)

  • Relative Growth Rate: 0.11 ± 0.05
  • Confidence: 7.24

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5N9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102149

Most Similar Human Ortholog: C9IZ83

TM-align score: 0.82 | RMSD: 2.58

Seq Identity: 0.40 | Length: 176 / 939

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000105821 DnaJ heat shock protein family (Hsp40) member C2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 7 54 29 71
disruptive 33 105 72 138
missense 20 91 65 111

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 17 119 40 68
disruptive 60 255 130 270
missense 36 203 100 169

PlasmoDB Total SNPs: 428

Non-coding: 330 | Synonymous: 54 | Nonsynonymous: 44 | Stop Codon: 0

Protein Information

Protein Length: 939 | Molecular Weight (kDa): 111.065

UniProt ID(s): Q8I5N9

PDB ID(s): None

Isoelectric Point: 8.96

Protein Domain Annotations:

Source Family ID Description
InterPro IPR001005 SANT/Myb domain
InterPro IPR001623 DnaJ domain
InterPro IPR009057 Homeobox-like domain superfamily
InterPro IPR036869 Chaperone J-domain superfamily
PFam PF00226 DnaJ domain
Superfamily SSF46565 Chaperone J-domain superfamily
Superfamily SSF46689 Homeobox-like domain superfamily

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108
30379851 Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. Briquet S, Ourimi A, ..., Vaquero C 10.1371/journal.pone.0205596