PF3D7_1217000

Genome location: Pf3D7_12_v3:674,321..675,112(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.31	0.81
Schizont	expressed	0.05	0.97
Gametocyte	possibly expressed	0.12	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1217000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.939 | MFS: -2.119 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5N8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532552

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	9	6	10
disruptive	2	9	6	16
missense	2	9	6	14

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	15	7	17
disruptive	7	28	16	39
missense	3	24	14	33

PlasmoDB Total SNPs: 25

Non-coding: 23 | Synonymous: 1 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 142 | Molecular Weight (kDa): 18.113

UniProt ID(s): Q8I5N8

PDB ID(s): None

Isoelectric Point: 11.35

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A