Product Description: multiple RNA-binding domain-containing protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030686 | 90S preribosome |
| Component | GO:0016607 | nuclear speck |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Process | GO:0045292 | mRNA cis splicing, via spliceosome |
| Process | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome |
| Process | GO:0034462 | small-subunit processome assembly |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 1.43 | 0.43 |
| Trophozoite | expressed | 0.95 | 0.52 |
| Schizont | expressed | 0.32 | 0.82 |
| Gametocyte | possibly expressed | 0.92 | 0.53 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1217200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 3 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -2.915 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1432800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A144A1F1
"Best" AlphaFill ligand hit: GTA (p1-7-methylguanosine-p3-adenosine-5',5'-triphosphate, Local RMSD=0.02) with 6D0Y (Global RMSD=8.11)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102169
Most Similar Human Ortholog: H0YIL2
TM-align score: 0.52 | RMSD: 3.34
Seq Identity: 0.34 | Length: 74 / 1119
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000122965 | RNA binding motif protein 19 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 17 | 53 | 24 | 69 |
| disruptive | 56 | 192 | 91 | 229 |
| missense | 29 | 150 | 81 | 180 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 27 | 102 | 46 | 74 |
| disruptive | 124 | 391 | 160 | 326 |
| missense | 55 | 301 | 129 | 218 |
PlasmoDB Total SNPs: 218
Non-coding: 74 | Synonymous: 93 | Nonsynonymous: 51 | Stop Codon: 0
Protein Length: 1119 | Molecular Weight (kDa): 131.113
UniProt ID(s): A0A144A1F1
PDB ID(s): None
Isoelectric Point: 9.58
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000504 | RNA recognition motif domain |
| InterPro | IPR034423 | Probable RNA-binding protein 19, RNA recognition motif 5 |
| InterPro | IPR035979 | RNA-binding domain superfamily |
| PFam | PF00076 | RNA recognition motif domain |
| Superfamily | SSF54928 | RNA-binding domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |