About Gene List

PF3D7_1217400

Genome location: Pf3D7_12_v3:685,730..689,481(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.15 0.92
Trophozoite possibly expressed 0.09 0.95
Schizont expressed 0.84 0.58
Gametocyte expressed 0.42 0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1217400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.994 | MFS: -2.511 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5N4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532382

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 11 37 20 49
disruptive 30 137 63 174
missense 21 110 51 136

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 19 79 39 46
disruptive 57 247 130 239
missense 34 189 97 168

PlasmoDB Total SNPs: 168

Non-coding: 63 | Synonymous: 62 | Nonsynonymous: 42 | Stop Codon: 1

Protein Information

Protein Length: 854 | Molecular Weight (kDa): 101.141

UniProt ID(s): Q8I5N4

PDB ID(s): None

Isoelectric Point: 6.41

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104