PF3D7_1217500

Genome location: Pf3D7_12_v3:691,395..694,623(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	1.04	0.52
Trophozoite	expressed	0.66	0.63
Schizont	expressed	0.53	0.67
Gametocyte	expressed	0.79	0.58

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1217500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.167 | MFS: -2.466 | #Insertions: 1

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1433100)

Relative Growth Rate: 0.14 ± 0.09
Confidence: 6.30

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5N3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533544

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 241

Non-coding: 198 | Synonymous: 30 | Nonsynonymous: 10 | Stop Codon: 3

Protein Information

Protein Length: 214 | Molecular Weight (kDa): 26.102

UniProt ID(s): Q8I5N3

PDB ID(s): None

Isoelectric Point: 10.09

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A