Product Description: anaphase-promoting complex subunit 10, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005680 | anaphase-promoting complex |
| Process | GO:0070979 | protein K11-linked ubiquitination |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.97 |
| Trophozoite | not expressed | 0.02 | 0.99 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1217600
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.574 | MFS: -2.208 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1433200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1433200)
Modification: Disrupted | RMgm-3905
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5N2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102604
Most Similar Human Ortholog: D6RA92
TM-align score: 0.85 | RMSD: 1.57
Seq Identity: 0.33 | Length: 145 / 298
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000164162 | anaphase promoting complex subunit 10 |
| ENSG00000285713 | novel transcript |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 17 | 6 | 27 |
| disruptive | 6 | 24 | 22 | 40 |
| missense | 6 | 22 | 22 | 38 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 38 | 12 | 23 |
| disruptive | 13 | 64 | 30 | 102 |
| missense | 10 | 53 | 23 | 65 |
PlasmoDB Total SNPs: 15
Non-coding: 0 | Synonymous: 6 | Nonsynonymous: 9 | Stop Codon: 0
Protein Length: 298 | Molecular Weight (kDa): 35.979
UniProt ID(s): Q8I5N2
PDB ID(s): None
Isoelectric Point: 8.24
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004939 | APC10/DOC domain |
| InterPro | IPR008979 | Galactose-binding-like domain superfamily |
| InterPro | IPR016901 | Anaphase-promoting complex subunit APC10/Doc1 |
| PFam | PF03256 | APC10/DOC domain |
| Superfamily | SSF49785 | Galactose-binding-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 24361936 | The anaphase promoting complex regulates yeast lifespan and rDNA stability bytargeting Fob1 for degradation | Menzel J, Malo ME, ..., Harkness TA | 10.1534/genetics.113.158949 |