PF3D7_1217700

Genome location: Pf3D7_12_v3:696,397..698,457(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.43	0.79
Trophozoite	expressed	0.44	0.74
Schizont	possibly expressed	0.33	0.78
Gametocyte	expressed	0.67	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1217700

Resistome Missense Mutations: N190D, N192D, D202N, N203D

Resistome Compounds with Missense Mutations: AN13762

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.434 | MFS: -2.649 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1433300)

Relative Growth Rate: 0.10 ± 0.14
Confidence: 5.27

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5N1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533390

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	27	11	22
disruptive	54	77	44	102
missense	31	48	36	82

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	47	13	34
disruptive	74	155	72	137
missense	36	117	58	94

PlasmoDB Total SNPs: 115

Non-coding: 35 | Synonymous: 21 | Nonsynonymous: 59 | Stop Codon: 0

Protein Information

Protein Length: 520 | Molecular Weight (kDa): 62.393

UniProt ID(s): Q8I5N1

PDB ID(s): None

Isoelectric Point: 4.44

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A