About Gene List

PF3D7_1217900

Genome location: Pf3D7_12_v3:700,202..702,357(+)

Genome classification: Core

Function and Localization

Product Description: PPPDE peptidase domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Process GO:0070646 protein modification by small protein removal

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.25 0.88
Trophozoite expressed 0.46 0.72
Schizont expressed 0.75 0.57
Gametocyte expressed 0.89 0.52

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1217900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.577 | #Insertions: 2

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1433500)

  • Relative Growth Rate: 0.91 ± 0.07
  • Confidence: 6.59

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1433500)

Modification: Disrupted | RMgm-3907

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5M9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102579

Most Similar Human Ortholog: Q6ICB0

TM-align score: 0.90 | RMSD: 1.69

Seq Identity: 0.35 | Length: 164 / 483

All Human Orthologs (OrthoMCL):

Gene ID Description
ENSG00000100418 desumoylating isopeptidase 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 24 20 34
disruptive 19 55 31 72
missense 16 54 28 61

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 11 61 21 28
disruptive 34 121 52 115
missense 27 105 44 85

PlasmoDB Total SNPs: 153

Non-coding: 102 | Synonymous: 32 | Nonsynonymous: 19 | Stop Codon: 0

Protein Information

Protein Length: 483 | Molecular Weight (kDa): 56.09

UniProt ID(s): Q8I5M9

PDB ID(s): None

Isoelectric Point: 6.24

Protein Domain Annotations:

Source Family ID Description
InterPro IPR008580 PPPDE peptidase domain
PFam PF05903 PPPDE peptidase domain
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104