PF3D7_1218100

Genome location: Pf3D7_12_v3:706,227..708,196(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	possibly expressed	0.03	0.98
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.04	0.97

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.54 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1433700)

Modification: Disrupted | RMgm-312

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3X6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533624

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	19	7	31
disruptive	3	23	12	57
missense	3	23	12	55

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	39	17	27
disruptive	9	66	47	119
missense	8	53	40	82

PlasmoDB Total SNPs: 154

Non-coding: 126 | Synonymous: 24 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 463 | Molecular Weight (kDa): 55.732

UniProt ID(s): A0A144A3X6

PDB ID(s): None

Isoelectric Point: 8.43

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094