PF3D7_1218200

Genome location: Pf3D7_12_v3:708,394..715,718(-)

Genome classification: Core

Function and Localization

Product Description: symplekin domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	1.38	0.43
Trophozoite	expressed	1.06	0.46
Schizont	expressed	1.19	0.42
Gametocyte	possibly expressed	0.98	0.51

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -3.095 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5M6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532969

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	98	75	143
disruptive	103	337	175	388
missense	69	270	150	318

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	29	216	96	150
disruptive	199	657	263	619
missense	119	516	214	432

PlasmoDB Total SNPs: 329

Non-coding: 106 | Synonymous: 98 | Nonsynonymous: 124 | Stop Codon: 1

Protein Information

Protein Length: 2134 | Molecular Weight (kDa): 256.152

UniProt ID(s): Q8I5M6

PDB ID(s): None

Isoelectric Point: 6.53

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022075	Symplekin C-terminal
PFam	PF12295	Symplekin C-terminal
Superfamily	N/A	N/A