Product Description: AP-2 complex subunit mu
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0031410 | cytoplasmic vesicle |
| Component | GO:0005829 | cytosol |
| Component | GO:0043231 | intracellular membrane-bounded organelle |
| Component | GO:0005634 | nucleus |
| Function | GO:0030276 | clathrin binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0035690 | cellular response to drug |
| Process | GO:0006897 | endocytosis |
| Process | GO:0009410 | response to xenobiotic stimulus |
| Process | GO:0020014 | schizogony |
| Process | GO:0016192 | vesicle-mediated transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.44 | 0.78 |
| Trophozoite | possibly expressed | 0.19 | 0.88 |
| Schizont | expressed | 0.76 | 0.58 |
| Gametocyte | not expressed | 0.21 | 0.87 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1218300
Resistome Missense Mutations: M584I
Resistome Compounds with Missense Mutations: GNF-Pf-3600
Resistome # Samples with Disruptive Mutations: 1 (1 missense, 1 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.22 | MFS: -3.402 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5M5
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=3.65) with 6JWQ (Global RMSD=20.14)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 15 | 42 | 19 | 42 |
| disruptive | 15 | 33 | 20 | 50 |
| missense | 10 | 30 | 15 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 22 | 70 | 32 | 48 |
| disruptive | 26 | 85 | 48 | 136 |
| missense | 19 | 61 | 36 | 78 |
PlasmoDB Total SNPs: 265
Non-coding: 220 | Synonymous: 31 | Nonsynonymous: 13 | Stop Codon: 1
Protein Length: 621 | Molecular Weight (kDa): 72.901
UniProt ID(s): A0A5J6BWC5, A0A5J6BWZ2, A0A5J6BXK9, A0A5J6BY30, A0A5J6BY97, A0A5J6BYL0, A0A5J6BYX7, A0A5J6BZG9, A0A5J6BZT3, A0A5J6BZU1, Q8I5M5
PDB ID(s): None
Isoelectric Point: 9.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001392 | Clathrin adaptor, mu subunit |
| InterPro | IPR011012 | Longin-like domain superfamily |
| InterPro | IPR028565 | Mu homology domain |
| InterPro | IPR036168 | AP-2 complex subunit mu, C-terminal superfamily |
| InterPro | IPR043532 | AP-2 complex subunit mu, N-terminal |
| PFam | PF00928 | Mu homology domain |
| Superfamily | SSF49447 | AP-2 complex subunit mu, C-terminal superfamily |
| Superfamily | SSF64356 | Longin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 25691625 | The Mu subunit of Plasmodium falciparum clathrin-associated adaptor protein 2modulates in vitro parasite response to artemisinin and quinine. | Henriques G, van Schalkwyk DA, ..., Sutherland CJ | 10.1128/AAC.04067-14 |
| 31896710 | A Kelch13-defined endocytosis pathway mediates artemisinin resistance in malariaparasites. | Birnbaum J, Scharf S, ..., Spielmann T | 10.1126/science.aax4735 |
| 32098816 | The Plasmodium falciparum Artemisinin Susceptibility-Associated A P-2 Adaptin mu Subunit is Clathrin Independent and Essential for Schizont Maturation | Henrici RC, Edwards RL, ..., Sutherland CJ | 10.1128/mBio.02918-19 |