PF3D7_1218400

Genome location: Pf3D7_12_v3:720,516..724,845(-)

Genome classification: Core

Function and Localization

Product Description: triose or hexose phosphate/phosphate translocator, putative

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005794	Golgi apparatus
Component	GO:0016020	membrane
Function	GO:0015297	antiporter activity
Function	GO:0022857	transmembrane transporter activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.81	0.62
Trophozoite	expressed	0.76	0.58
Schizont	expressed	0.56	0.66
Gametocyte	expressed	0.69	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.15 | #Insertions: 3

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1434000)

Relative Growth Rate: 0.92 ± 0.10
Confidence: 5.95

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1436400)

Modification: Disrupted | RMgm-4768

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5M4

"Best" AlphaFill ligand hit: 5GP (guanosine-5'-monophosphate, Local RMSD=0.77) with 6QSK (Global RMSD=7.77)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_102765

Most Similar Human Ortholog: Q9NQQ7

TM-align score: 0.67 | RMSD: 4.05

Seq Identity: 0.19 | Length: 306 / 478

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000080189	solute carrier family 35 member C2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	19	20	45
disruptive	4	14	11	24
missense	4	10	10	21

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	57	27	40
disruptive	13	49	31	81
missense	8	37	25	61

PlasmoDB Total SNPs: 315

Non-coding: 268 | Synonymous: 42 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 478 | Molecular Weight (kDa): 54.722

UniProt ID(s): Q8I5M4

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR004853	Sugar phosphate transporter domain
PFam	PF03151	Sugar phosphate transporter domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
11152613	Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes.	Krogh A, Larsson B, von Heijne G, Sonnhammer EL	10.1006/jmbi.2000.4315
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097