Product Description: dynamin-like protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005737 | cytoplasm |
| Component | GO:0016020 | membrane |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0005634 | nucleus |
| Function | GO:0005525 | GTP binding |
| Function | GO:0003924 | GTPase activity |
| Function | GO:0008017 | microtubule binding |
| Process | GO:0000266 | mitochondrial fission |
| Process | GO:0007005 | mitochondrion organization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 1.33 | 0.46 |
| Trophozoite | possibly expressed | 0.42 | 0.76 |
| Schizont | expressed | 0.31 | 0.81 |
| Gametocyte | not expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1218500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.13 | MFS: -3.146 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5M3
"Best" AlphaFill ligand hit: GNH (aminophosphonic acid-guanylate ester, Local RMSD=1.44) with 3W6N (Global RMSD=4.94)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 14 | 44 | 25 | 65 |
| disruptive | 4 | 24 | 25 | 58 |
| missense | 4 | 22 | 22 | 48 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 29 | 101 | 38 | 70 |
| disruptive | 11 | 99 | 56 | 171 |
| missense | 4 | 71 | 39 | 113 |
PlasmoDB Total SNPs: 304
Non-coding: 262 | Synonymous: 36 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 1061 | Molecular Weight (kDa): 122.756
UniProt ID(s): Q8I5M3
PDB ID(s): None
Isoelectric Point: 6.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR022812 | Dynamin superfamily |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00350 | Dynamin superfamily |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 30947298 | A unique dynamin-related protein is essential for mitochondrial fission inToxoplasma gondii. | Melatti C, Pieperhoff M, ..., Meissner M | 10.1371/journal.ppat.1007512 |
| 26090798 | Conditional U1 Gene Silencing in Toxoplasma gondii | Pieperhoff MS, Pall GS, ..., Meissner M | 10.1371/journal.pone.0130356 |