PF3D7_1218700

Genome location: Pf3D7_12_v3:736,335..737,825(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.02	0.98
Gametocyte	not expressed	0.19	0.88

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.301 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1434300)

Modification: Disrupted | RMgm-3912

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5M1

"Best" AlphaFill ligand hit: ABH (2(s)-amino-6-boronohexanoic acid, Local RMSD=0.57) with 3MMR (Global RMSD=21.46)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532874

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	17	13	41
disruptive	9	76	48	110
missense	9	76	45	99

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	49	17	44
disruptive	17	189	82	177
missense	15	171	74	109

PlasmoDB Total SNPs: 31

Non-coding: 0 | Synonymous: 19 | Nonsynonymous: 11 | Stop Codon: 1

Protein Information

Protein Length: 496 | Molecular Weight (kDa): 58.798

UniProt ID(s): Q8I5M1

PDB ID(s): None

Isoelectric Point: 6.25

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A