PF3D7_1218800 (PSOP17)

Genome location: Pf3D7_12_v3:737,900..740,324(-)

Genome classification: Core

Function and Localization

Product Description: secreted ookinete protein, putative

SignalP Peptide: MLLYLYKIWYLILLWLYTHN

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	possibly expressed	0.02	0.99
Schizont	possibly expressed	0.02	0.99
Gametocyte	expressed	0.48	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.565 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1434400)

Relative Growth Rate: 1.03 ± 0.13
Confidence: 5.51

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1434400)

Modification: Disrupted | RMgm-3913

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5L9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_123570

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	9	13	21
disruptive	4	11	3	22
missense	4	11	3	18

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	28	11	21
disruptive	7	36	23	67
missense	7	26	20	51

PlasmoDB Total SNPs: 111

Non-coding: 96 | Synonymous: 11 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 349 | Molecular Weight (kDa): 39.631

UniProt ID(s): Q8I5L9

PDB ID(s): None

Isoelectric Point: 6.67

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily
PFam	PF13385	N/A
Superfamily	SSF49899	Concanavalin A-like lectin/glucanase domain superfamily