PF3D7_1218900

Genome location: Pf3D7_12_v3:740,675..743,452(-)

Genome classification: Core

Function and Localization

Product Description: WD repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.22	0.89
Trophozoite	possibly expressed	0.54	0.71
Schizont	possibly expressed	0.15	0.90
Gametocyte	not expressed	0.89	0.54

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1218900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.106 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5L8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533091

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	39	20	39
disruptive	50	147	63	195
missense	32	102	48	152

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	8	69	33	45
disruptive	104	317	123	241
missense	59	213	102	166

PlasmoDB Total SNPs: 165

Non-coding: 56 | Synonymous: 63 | Nonsynonymous: 46 | Stop Codon: 0

Protein Information

Protein Length: 717 | Molecular Weight (kDa): 85.199

UniProt ID(s): Q8I5L8

PDB ID(s): None

Isoelectric Point: 5.58

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily