About Gene List

PF3D7_1219000 (FRM2)

Genome location: Pf3D7_12_v3:744,724..756,058(+)

Genome classification: Core

Function and Localization

Product Description: formin 2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Function GO:0003779 actin binding
Process GO:0030041 actin filament polymerization
Process GO:0045010 actin nucleation
Process GO:0000910 cytokinesis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring expressed 0.43 0.81
Trophozoite expressed 1.10 0.46
Schizont expressed 1.59 0.38
Gametocyte possibly expressed 1.32 0.39

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1219000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.285 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_119726

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 31 125 65 162
disruptive 104 346 157 449
missense 69 294 149 366

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 46 241 92 167
disruptive 185 706 309 671
missense 108 575 244 438

PlasmoDB Total SNPs: 529

Non-coding: 200 | Synonymous: 142 | Nonsynonymous: 185 | Stop Codon: 2

Protein Information

Protein Length: 2974 | Molecular Weight (kDa): 349.765

UniProt ID(s): Q8I5L7

PDB ID(s): None

Isoelectric Point: 8

Protein Domain Annotations:

Source Family ID Description
InterPro IPR015425 Formin, FH2 domain
PFam PF02181 Formin, FH2 domain
Superfamily SSF101447 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
18329618 A malaria parasite formin regulates actin polymerization and localizes to theparasite-erythrocyte moving junction during invasion. Baum J, Tonkin CJ, ..., Cowman AF 10.1016/j.chom.2008.02.006
31322501 Formin-2 drives polymerisation of actin filaments enabling segregation ofapicoplasts and cytokinesis in Plasmodium falciparum Stortz JF, Del Rosario M, ..., Das S 10.7554/eLife.49030
30753127 Three F-actin assembly centers regulate organelle inheritance, cell-cellcommunication and motility in Toxoplasma gondii Tosetti N, Dos Santos Pacheco N, Soldati-Favre D, Jacot D 10.7554/eLife.42669
29121591 Proteomic and enzymatic response under Cr(VI) overload in yeast isolated fromtextile-dye industry effluent Irazusta V, Bernal AR, Estevez MC, de Figueroa LIC 10.1016/j.ecoenv.2017.10.076
37596377 Plasmodium falciparum formins are essential for invasion and sexual stagedevelopment Collier S, Pietsch E, ..., Dixon MWA 10.1038/s42003-023-05233-y
25864423 Crystal structure of the fungal nitroreductase Frm2 from Saccharomycescerevisiae Song HN, Jeong DG, ..., Woo EJ 10.1002/pro.2686