Product Description: clathrin heavy chain, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071439 | clathrin complex |
| Component | GO:0030125 | clathrin vesicle coat |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0032051 | clathrin light chain binding |
| Process | GO:0006898 | receptor-mediated endocytosis |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.76 | 0.65 |
| Trophozoite | expressed | 1.39 | 0.36 |
| Schizont | expressed | 0.85 | 0.59 |
| Gametocyte | expressed | 0.92 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1219100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -3.091 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1434700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5L6
"Best" AlphaFill ligand hit: APC (alpha,beta-methyleneadenosine-5'-triphosphate, Local RMSD=6.89) with 4L39 (Global RMSD=23.78)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q00610 | Clathrin heavy chain 1 | Homo sapiens | HOGENOM, OrthoDB | CHEMBL3110181 |
Ortholog Group (OrthoMCL): OG6_101144
Most Similar Human Ortholog: J3QL20
TM-align score: 0.88 | RMSD: 1.52
Seq Identity: 0.28 | Length: 95 / 1997
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000070371 | clathrin heavy chain like 1 |
| ENSG00000141367 | clathrin heavy chain |
Protein Length: 1997 | Molecular Weight (kDa): 232.95
UniProt ID(s): Q8I5L6
PDB ID(s): None
Isoelectric Point: 6.33
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000547 | Clathrin, heavy chain/VPS, 7-fold repeat |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR016025 | Clathrin heavy chain, N-terminal |
| InterPro | IPR016341 | Clathrin, heavy chain |
| InterPro | IPR022365 | Clathrin, heavy chain, propeller repeat |
| PFam | PF00637 | Clathrin, heavy chain/VPS, 7-fold repeat |
| PFam | PF01394 | Clathrin, heavy chain, propeller repeat |
| Superfamily | SSF48371 | Armadillo-type fold |
| Superfamily | SSF50989 | Clathrin heavy chain, N-terminal |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 31 | 79 | 72 | 135 |
| disruptive | 34 | 120 | 74 | 202 |
| missense | 18 | 104 | 69 | 176 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 38 | 226 | 77 | 104 |
| disruptive | 67 | 261 | 169 | 346 |
| missense | 31 | 214 | 139 | 242 |
PlasmoDB Total SNPs: 251
Non-coding: 112 | Synonymous: 103 | Nonsynonymous: 36 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |