Product Description: raf kinase inhibitor
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0008429 | phosphatidylethanolamine binding |
| Function | GO:0019887 | protein kinase regulator activity |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.98 |
| Trophozoite | possibly expressed | 0.00 | 1.00 |
| Schizont | possibly expressed | 0.00 | 1.00 |
| Gametocyte | not expressed | 0.04 | 0.97 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1219700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.174 | MFS: -2.863 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q7KQK1
"Best" AlphaFill ligand hit: OPE (phosphoric acid mono-(2-amino-ethyl) ester, Local RMSD=0.66) with 2IQX (Global RMSD=2.64)
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 11 | 4 | 10 |
| disruptive | 2 | 5 | 5 | 11 |
| missense | 2 | 5 | 4 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 7 | 5 |
| disruptive | 3 | 15 | 16 | 42 |
| missense | 3 | 13 | 13 | 26 |
PlasmoDB Total SNPs: 14
Non-coding: 0 | Synonymous: 8 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 190 | Molecular Weight (kDa): 21.576
UniProt ID(s): P54189, Q549B0, Q7KQK1
PDB ID(s): 2R77
Isoelectric Point: 8.63
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001858 | Phosphatidylethanolamine-binding, conserved site |
| InterPro | IPR008914 | Phosphatidylethanolamine-binding protein |
| InterPro | IPR035810 | Phosphatidylethanolamine-binding protein, eukaryotic |
| InterPro | IPR036610 | PEBP-like superfamily |
| PFam | PF01161 | Phosphatidylethanolamine-binding protein |
| Superfamily | SSF49777 | PEBP-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 17123645 | Raf kinase inhibitor protein affects activity of Plasmodium falciparumcalcium-dependent protein kinase 1. | Kugelstadt D, Winter D, ..., Kappes B | https://pubmed.ncbi.nlm.nih.gov/17123645/ |
| 37963558 | A systems-level analysis of the mutually antagonistic roles of RKIP and BACH1 indynamics of cancer cell plasticity | Shyam S, Ramu S, Sehgal M, Jolly MK | 10.1098/rsif.2023.0389 |
| 37894300 | Cross-Talks between RKIP and YY1 through a Multilevel Bioinformatics Pan-CancerAnalysis | Baritaki S, Zaravinos A | 10.3390/cancers15204932 |