PF3D7_1219800

Genome location: Pf3D7_12_v3:795,157..795,318(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	no data	N/A	N/A
Ring	no data	0.00	1.00
Trophozoite	no data	0.00	1.00
Schizont	no data	0.00	1.00
Gametocyte	no data	0.01	0.99

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1219800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.169 | MFS: -3.149 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1435000)

Relative Growth Rate: 1.01 ± 0.14
Confidence: 5.33

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1435000)

Modification: Disrupted | RMgm-3916

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3K7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532539

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	rare	doubleton	singleton
synonymous	1	1	1
disruptive	1	1	3
missense	1	1	3

Any inclusion in genotype call

variant type	rare	singleton
synonymous	2	4
disruptive	5	11
missense	4	4

PlasmoDB Total SNPs: 4

Non-coding: 0 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 53 | Molecular Weight (kDa): 6.272

UniProt ID(s): C6S3K7

PDB ID(s): None

Isoelectric Point: 3.55

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A