Product Description: ribulose-phosphate 3-epimerase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.1.3.1 (Ribulose-phosphate 3-epimerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Function | GO:0046872 | metal ion binding |
| Function | GO:0004750 | ribulose-phosphate 3-epimerase activity |
| Process | GO:0044262 | cellular carbohydrate metabolic process |
| Process | GO:0019323 | pentose catabolic process |
| Process | GO:0006098 | pentose-phosphate shunt |
| Process | GO:0009052 | pentose-phosphate shunt, non-oxidative branch |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.02 | 0.99 |
| Trophozoite | expressed | 0.17 | 0.88 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | expressed | 0.16 | 0.90 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1219900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3.096 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5L3
"Best" AlphaFill ligand hit: IMP (inosinic acid, Local RMSD=0.48) with 4MY1 (Global RMSD=3.98)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.1.3.1 | ribulose-phosphate 3-epimerase | BRENDA SOAP query unsuccessful |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100819
Most Similar Human Ortholog: C9J9T0
TM-align score: 0.95 | RMSD: 1.07
Seq Identity: 0.47 | Length: 188 / 227
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197713 | ribulose-5-phosphate-3-epimerase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 11 | 5 | 14 |
| disruptive | 4 | 17 | 9 | 24 |
| missense | 4 | 17 | 9 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 23 | 4 | 21 |
| disruptive | 4 | 44 | 16 | 33 |
| missense | 4 | 39 | 13 | 29 |
PlasmoDB Total SNPs: 45
Non-coding: 36 | Synonymous: 6 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 227 | Molecular Weight (kDa): 25.549
UniProt ID(s): Q8I5L3
PDB ID(s): 1TQX
Isoelectric Point: 6.49
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000056 | Ribulose-phosphate 3-epimerase-like |
| InterPro | IPR011060 | Ribulose-phosphate binding barrel |
| InterPro | IPR026019 | Ribulose-phosphate 3-epimerase |
| PFam | PF00834 | Ribulose-phosphate 3-epimerase-like |
| Superfamily | SSF51366 | Ribulose-phosphate binding barrel |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16304640 | Structure of a ribulose 5-phosphate 3-epimerase from Plasmodium falciparum. | Caruthers J, Bosch J, ..., Hol WG | 10.1002/prot.20764 |