PF3D7_1220000

Genome location: Pf3D7_12_v3:798,304..799,611(-)

Genome classification: Core

Function and Localization

Product Description: female development protein FD4, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.02	0.99
Schizont	not expressed	0.01	1.00
Gametocyte	expressed	0.33	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1220000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.214 | MFS: -2.68 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1435200)

Relative Growth Rate: 0.91 ± 0.19
Confidence: 4.73

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1435200)

Modification: Disrupted | RMgm-5075

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5L2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532598

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	23	8	16
disruptive	7	28	13	36
missense	7	26	9	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	32	18	18
disruptive	11	66	17	60
missense	10	50	13	46

PlasmoDB Total SNPs: 26

Non-coding: 0 | Synonymous: 12 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 435 | Molecular Weight (kDa): 51.142

UniProt ID(s): Q8I5L2

PDB ID(s): None

Isoelectric Point: 8.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A