PF3D7_1220300

Genome location: Pf3D7_12_v3:807,101..816,204(+)

Genome classification: Core

Function and Localization

Product Description: cell cycle associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.08	0.96
Trophozoite	expressed	0.78	0.62
Schizont	expressed	0.98	0.57
Gametocyte	possibly expressed	0.61	0.67

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1220300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.97 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_139437

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	22	120	66	140
disruptive	60	255	136	416
missense	49	233	126	371

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	40	227	93	173
disruptive	144	637	325	709
missense	93	526	269	480

PlasmoDB Total SNPs: 289

Non-coding: 96 | Synonymous: 121 | Nonsynonymous: 72 | Stop Codon: 0

Protein Information

Protein Length: 2705 | Molecular Weight (kDa): 324.079

UniProt ID(s): Q8I5L0

PDB ID(s): None

Isoelectric Point: 9.63

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR000408	Regulator of chromosome condensation, RCC1
InterPro	IPR009091	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II
PFam	PF00612	IQ motif, EF-hand binding site
PFam	PF13540
Superfamily	SSF50985	Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
23181666	Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum.	Oehring SC, Woodcroft BJ, ..., Voss TS	10.1186/gb-2012-13-11-r108