About Gene List

PF3D7_1220600

Genome location: Pf3D7_12_v3:820,586..822,198(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MLLRVFLYFILVKIYQC

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0020011 apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.03 0.98
Trophozoite possibly expressed 0.17 0.88
Schizont expressed 0.04 0.97
Gametocyte not expressed 0.11 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1220600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.444 | MFS: -3.248 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5K7

"Best" AlphaFill ligand hit: FAD (flavin-adenine dinucleotide, Local RMSD=0.09) with 5JWA (Global RMSD=20.69)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_147971

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 1 21 12 16
disruptive 6 36 32 40
missense 5 35 31 37

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 4 34 16 15
disruptive 12 93 41 92
missense 8 78 31 46

PlasmoDB Total SNPs: 56

Non-coding: 33 | Synonymous: 11 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 338 | Molecular Weight (kDa): 40.678

UniProt ID(s): Q8I5K7

PDB ID(s): None

Isoelectric Point: 9.41

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094
30212465 Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. Boucher MJ, Ghosh S, ..., Yeh E 10.1371/journal.pbio.2005895