Product Description: heterochromatin protein 1
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0000785 | chromatin |
| Component | GO:0000792 | heterochromatin |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0034399 | nuclear periphery |
| Component | GO:0005634 | nucleus |
| Function | GO:0062072 | H3K9me3 modified histone binding |
| Function | GO:0003682 | chromatin binding |
| Function | GO:0005515 | protein binding |
| Process | GO:0008283 | cell population proliferation |
| Process | GO:0006333 | chromatin assembly or disassembly |
| Process | GO:0031507 | heterochromatin assembly |
| Process | GO:0031935 | obsolete regulation of chromatin silencing |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.06 | 0.97 |
| Trophozoite | expressed | 0.34 | 0.78 |
| Schizont | expressed | 0.28 | 0.81 |
| Gametocyte | expressed | 0.14 | 0.91 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1220900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.129 | MFS: -3.236 | #Insertions: 0
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1436100)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1436100)
Modification: Disrupted | RMgm-3922
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5K4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 1 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 2 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 125
Non-coding: 117 | Synonymous: 6 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 266 | Molecular Weight (kDa): 31.018
PDB ID(s): None
Isoelectric Point: 10.09
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000953 | Chromo/chromo shadow domain |
| InterPro | IPR016197 | Chromo-like domain superfamily |
| InterPro | IPR023779 | Chromo domain, conserved site |
| InterPro | IPR023780 | Chromo domain |
| PFam | PF00385 | Chromo domain |
| Superfamily | SSF54160 | Chromo-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 19270070 | Plasmodium falciparum heterochromatin protein 1 binds to tri-methylated histone 3lysine 9 and is linked to mutually exclusive expression of var genes. | Perez-Toledo K, Rojas-Meza AP, ..., Hernandez-Rivas R | 10.1093/nar/gkp115 |
| 19730695 | Plasmodium falciparum heterochromatin protein 1 marks genomic loci linked tophenotypic variation of exported virulence factors. | Flueck C, Bartfai R, ..., Voss TS | 10.1371/journal.ppat.1000569 |
| 20195509 | A major role for the Plasmodium falciparum ApiAP2 protein PfSIP2 in chromosomeend biology. | Flueck C, Bartfai R, ..., Voss TS | 10.1371/journal.ppat.1000784 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29183721 | Role of Chromatin assembly factor 1 in DNA replication of Plasmodium falciparum. | Gupta MK, Agarawal M, ..., Dhar SK | 10.1016/j.bbrc.2017.11.131 |
| 29503181 | Comparative Heterochromatin Profiling Reveals Conserved and Unique EpigenomeSignatures Linked to Adaptation and Development of Malaria Parasites. | Fraschka SA, Filarsky M, ..., Voss TS | 10.1016/j.chom.2018.01.008 |
| 29539423 | A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role inHepatocyte Infection. | Zanghi G, Vembar SS, ..., Scherf A | 10.1016/j.celrep.2018.02.075 |
| 29590075 | GDV1 induces sexual commitment of malaria parasites by antagonizing HP1-dependentgene silencing. | Filarsky M, Fraschka SA, ..., Voss TS | 10.1126/science.aan6042 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 31723180 | Mapping and functional analysis of heterochromatin protein 1 phosphorylation inthe malaria parasite Plasmodium falciparum. | Bui HTN, Niederwieser I, ..., Voss TS | 10.1038/s41598-019-53325-9 |
| 31728527 | Epigenetic reader complexes of the human malaria parasite, Plasmodium falciparum. | Hoeijmakers WAM, Miao J, ..., Bartfai R | 10.1093/nar/gkz1044 |
| 33536327 | Investigation of Heterochromatin Protein 1 Function in the Malaria Parasite Plasmodium falciparum Using a Conditional Domain Deletion and Swapping Approach | Bui HTN, Passecker A, Brancucci NMB, Voss TS | 10.1128/mSphere.01220-20 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 38289024 | Heat stress-induced activation of MAPK pathway attenuates Atf1-dependentepigenetic inheritance of heterochromatin in fission yeast | Sun L, Liu L, ..., Jin QW | 10.7554/eLife.90525 |