About Gene List

PF3D7_1221100

Genome location: Pf3D7_12_v3:846,961..849,446(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: MKDILLLVILASFLKTFIC

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite possibly expressed N/A N/A
Ring possibly expressed nd nd
Trophozoite expressed nd nd
Schizont expressed nd nd
Gametocyte expressed nd nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.12 | MFS: -2.71 | #Insertions: 0

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1436300)

  • Relative Growth Rate: 1.06 ± 0.11
  • Confidence: 5.81

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1436300)

Modification: Disrupted | RMgm-3924

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A1U0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533319

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 14 8 18
disruptive 8 31 13 33
missense 8 27 13 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 8 22 13 19
disruptive 19 51 30 55
missense 12 45 28 43

PlasmoDB Total SNPs: 145

Non-coding: 125 | Synonymous: 12 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 260 | Molecular Weight (kDa): 30.421

UniProt ID(s): A0A144A1U0

PDB ID(s): None

Isoelectric Point: 7.35

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

No associated publications