PF3D7_1221200

Genome location: Pf3D7_12_v3:849,634..850,735(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.98
Trophozoite	possibly expressed	0.15	0.90
Schizont	not expressed	0.03	0.98
Gametocyte	possibly expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -2.835 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5K1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533227

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	7	7	12
disruptive	1	5	4	14
missense	1	5	3	13

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	19	6	8
disruptive	3	21	12	39
missense	2	14	8	28

PlasmoDB Total SNPs: 67

Non-coding: 63 | Synonymous: 4 | Nonsynonymous: 0 | Stop Codon: 0

Protein Information

Protein Length: 106 | Molecular Weight (kDa): 12.228

UniProt ID(s): Q8I5K1

PDB ID(s): None

Isoelectric Point: 8.89

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A