PF3D7_1221300

Genome location: Pf3D7_12_v3:850,987..855,507(-)

Genome classification: Core

Function and Localization

Product Description: EF hand domain-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.08	0.96
Trophozoite	not expressed	0.41	0.77
Schizont	possibly expressed	1.02	0.52
Gametocyte	expressed	0.56	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -2.534 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1436500)

Modification: Other | RMgm-419

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5K0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_156446

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	9	44	15	58
disruptive	7	91	52	110
missense	7	89	50	103

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	81	25	63
disruptive	22	197	89	186
missense	17	179	82	144

PlasmoDB Total SNPs: 198

Non-coding: 156 | Synonymous: 26 | Nonsynonymous: 16 | Stop Codon: 0

Protein Information

Protein Length: 711 | Molecular Weight (kDa): 84.218

UniProt ID(s): Q8I5K0

PDB ID(s): None

Isoelectric Point: 9.54

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR011992	EF-hand domain pair
PFam	N/A	N/A
Superfamily	SSF47473	EF-hand domain pair

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104