PF3D7_1221400 (IMC1h)

Genome location: Pf3D7_12_v3:856,817..859,199(+)

Genome classification: Core

Function and Localization

Product Description: inner membrane complex protein 1h, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0070258	inner membrane pellicle complex

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.01	1.00
Trophozoite	expressed	0.01	1.00
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.88	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.951 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1436600)

Relative Growth Rate: 1.00 ± 0.25
Confidence: 4.14

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1436600)

Modification: Mutated | RMgm-4676

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5J9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_162858

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	30	18	43
disruptive	14	39	27	72
missense	13	39	26	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	9	52	26	42
disruptive	23	91	56	104
missense	18	83	50	73

PlasmoDB Total SNPs: 55

Non-coding: 37 | Synonymous: 7 | Nonsynonymous: 11 | Stop Codon: 0

Protein Information

Protein Length: 524 | Molecular Weight (kDa): 60.115

UniProt ID(s): Q8I5J9

PDB ID(s): None

Isoelectric Point: 8.06

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR022086	Inner membrane complex protein
PFam	PF12314	Inner membrane complex protein
Superfamily	N/A	N/A

Associated Publications

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
18359944	Alveolins, a new family of cortical proteins that define the protist infrakingdomAlveolata.	Gould SB, Tham WH, ..., Waller RF	10.1093/molbev/msn070
22844474	The alveolin IMC1h is required for normal ookinete and sporozoite motilitybehaviour and host colonisation in Plasmodium berghei	Volkmann K, Pfander C, ..., Brochet M	10.1371/journal.pone.0041409
21098480	Malaria IMC1 membrane skeleton proteins operate autonomously and participate inmotility independently of cell shape	Tremp AZ, Dessens JT	10.1074/jbc.M110.187195
31428588	Distinct Functional Contributions by the Conserved Domains of the MalariaParasite Alveolin IMC1h	Coghlan MP, Tremp AZ, ..., Dessens JT	10.3389/fcimb.2019.00266