About Gene List

PF3D7_1221500

Genome location: Pf3D7_12_v3:859,958..863,117(+)

Genome classification: Core

Function and Localization

Product Description: heptatricopeptide repeat-containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005737 cytoplasm
Component GO:0005739 mitochondrion
Function GO:0051082 unfolded protein binding
Process GO:0006612 protein targeting to membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite expressed 0.18 0.88
Schizont possibly expressed 0.01 0.99
Gametocyte not expressed 0.12 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.125 | MFS: -3.128 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1436700)

  • Relative Growth Rate: 0.05 ± 0.05
  • Confidence: 7.57

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1436700)

Modification: Tagged | RMgm-4466

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5J8

"Best" AlphaFill ligand hit: BMF (bromosporine, Local RMSD=0.59) with 5U9N (Global RMSD=33.84)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_160744

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 6 35 17 43
disruptive 23 54 52 146
missense 11 50 49 133

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 65 29 62
disruptive 30 167 100 183
missense 15 148 87 129

PlasmoDB Total SNPs: 84

Non-coding: 13 | Synonymous: 31 | Nonsynonymous: 39 | Stop Codon: 1

Protein Information

Protein Length: 842 | Molecular Weight (kDa): 99.32

UniProt ID(s): Q8I5J8

PDB ID(s): None

Isoelectric Point: 8.92

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
30102371 Identification of clustered organellar short (cos) RNAs and of a conserved familyof organellar RNA-binding proteins, the heptatricopeptide repeat proteins, in themalaria parasite. Hillebrand A, Matz JM, ..., Schmitz-Linneweber C 10.1093/nar/gky710
34494883 A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. van Esveld SL, Meerstein-Kessel L, ..., Huynen MA 10.1128/mSphere.00614-21