PF3D7_1221800

Genome location: Pf3D7_12_v3:868,784..872,311(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: MIFGFLLLNVLLCVLM

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.09	0.96
Trophozoite	expressed	0.73	0.60
Schizont	expressed	0.63	0.65
Gametocyte	expressed	0.34	0.81

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221800

Resistome Missense Mutations: E368K

Resistome Compounds with Missense Mutations: BI-2536

Resistome # Samples with Disruptive Mutations: 1 (1 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.309 | MFS: -2.637 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1437000)

Relative Growth Rate: 0.02 ± 0.05
Confidence: 7.38

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5J5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_134710

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	25	20	38
disruptive	6	47	18	58
missense	6	44	18	49

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	63	22	46
disruptive	22	98	52	112
missense	13	84	46	91

PlasmoDB Total SNPs: 116

Non-coding: 56 | Synonymous: 32 | Nonsynonymous: 26 | Stop Codon: 2

Protein Information

Protein Length: 702 | Molecular Weight (kDa): 83.238

UniProt ID(s): Q8I5J5

PDB ID(s): None

Isoelectric Point: 8.97

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR008974	TRAF-like
PFam	N/A	N/A
Superfamily	SSF49599	TRAF-like

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
16267556	A protein interaction network of the malaria parasite Plasmodium falciparum.	LaCount DJ, Vignali M, ..., Hughes RE	10.1038/nature04104
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895