PF3D7_1221900

Genome location: Pf3D7_12_v3:871,737..876,247(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 5

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.53	0.38
Trophozoite	expressed	0.36	0.81
Schizont	expressed	0.42	0.75
Gametocyte	not expressed	0.25	0.86

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1221900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.23 | MFS: -3.345 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5J4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532343

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	13	48	20	47
disruptive	42	155	66	137
missense	30	120	49	108

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	18	84	33	58
disruptive	73	266	109	228
missense	49	198	86	156

PlasmoDB Total SNPs: 211

Non-coding: 101 | Synonymous: 58 | Nonsynonymous: 52 | Stop Codon: 0

Protein Information

Protein Length: 859 | Molecular Weight (kDa): 101.143

UniProt ID(s): Q8I5J4

PDB ID(s): None

Isoelectric Point: 8.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A