PF3D7_1222100

Genome location: Pf3D7_12_v3:879,217..881,186(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

More info:

• Malaria Parasite Metabolic Pathways (MPMP) Link
• BiGG Metabolic Model Link
• STRING Interaction Network Link

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1222100

Resistome Missense Mutations: N220D

Resistome Compounds with Missense Mutations: AN10248, AN13762

Resistome # Samples with Disruptive Mutations: 5 (5 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -3.033 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5J2

"Best" AlphaFill ligand hit: NUP (, Local RMSD=0.36) with 2Q8Z (Global RMSD=11.53)

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_215361

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

No passing variants found

PlasmoDB Total SNPs: 85

Non-coding: 61 | Synonymous: 12 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 518 | Molecular Weight (kDa): 60.182

UniProt ID(s): Q8I5J2

PDB ID(s): None

Isoelectric Point: 8.85

Protein Domain Annotations: