Product Description: endoplasmin, putative
SignalP Peptide: MKLNNIYSFFFLFFVLCVIQENVRRVLC
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0009986 | cell surface |
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0020020 | food vacuole |
| Component | GO:0005634 | nucleus |
| Component | GO:0048471 | perinuclear region of cytoplasm |
| Function | GO:0003723 | RNA binding |
| Function | GO:0051082 | unfolded protein binding |
| Process | GO:0006457 | protein folding |
| Process | GO:0009408 | response to heat |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.53 | 0.76 |
| Trophozoite | expressed | 1.78 | 0.24 |
| Schizont | expressed | 0.69 | 0.66 |
| Gametocyte | expressed | 1.91 | 0.22 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1222300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.148 | MFS: -2.824 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1437300)
RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1437300)
Modification: Tagged | RMgm-1481
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I0V4
"Best" AlphaFill ligand hit: 2GJ (5-[2,4-dihydroxy-5-(1-methylethyl)phenyl]-n-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide, Local RMSD=0.07) with 7K9S (Global RMSD=1.27)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| P07901 | Heat shock protein HSP 90-alpha | Mus musculus | HOGENOM, OrthoDB | CHEMBL191786CHEMBL364456CHEMBL195869CHEMBL370247... |
| C4YTQ8 | ATP-dependent molecular chaperone HSP82 | Candida albicans | HOGENOM, OrthoMCL | MLS000089236MLS000034735MLS000075315MLS000027935... |
| P14625 | Endoplasmin | HOGENOM, OrthoDB | CHEMBL3235333CHEMBL3235334CHEMBL3235335CHEMBL3235336... | |
| P08238 | Heat shock protein HSP 90-beta | Homo sapiens | HOGENOM, OrthoDB | TanespimycinMicrolactone, 1VER-00063579CCT018159 analog 2... |
| P02829 | ATP-dependent molecular chaperone HSP82 | Saccharomyces cerevisiae | HOGENOM, OrthoDB, OrthoMCL | Purine-Based Inhibitor 11Microlactone, 1Microlactone, 1Microlactone, 15a... |
| Q76LV2 | Heat shock protein HSP 90-alpha | HOGENOM, OrthoDB | US10889552, Compound 11aUS10889552, Compound 11bUS10889552, Compound 11cUS10889552, Compound 11d... | |
| P07900 | Heat shock protein HSP 90-alpha | Homo sapiens | HOGENOM, OrthoDB | Benzisoxazole, 6Benzisoxazole, 15Benzisoxazole, 17Benzisoxazole, 18... |
| P46598 | Heat shock protein 90 homolog | HOGENOM, OrthoDB, OrthoMCL | US11312722, Compound 20US11312722, Compound 21US11312722, Compound 22US11312722, Compound 23... | |
| P41148 | Endoplasmin | Canis familiaris | OrthoDB, OrthoMCL | CHEMBL211295CHEMBL377559CHEMBL209356Tanespimycin... |
Ortholog Group (OrthoMCL): OG6_100204
Most Similar Human Ortholog: G3V2J8
TM-align score: 0.78 | RMSD: 2.11
Seq Identity: 0.46 | Length: 149 / 821
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000080824 | heat shock protein 90 alpha family class A member 1 |
| ENSG00000096384 | heat shock protein 90 alpha family class B member 1 |
| ENSG00000166598 | heat shock protein 90 beta family member 1 |
Protein Length: 821 | Molecular Weight (kDa): 95.018
UniProt ID(s): Q8I0V4
Isoelectric Point: 5.04
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001404 | Heat shock protein Hsp90 family |
| InterPro | IPR003594 | Histidine kinase/HSP90-like ATPase |
| InterPro | IPR019805 | Heat shock protein Hsp90, conserved site |
| InterPro | IPR020568 | Ribosomal protein S5 domain 2-type fold |
| InterPro | IPR020575 | Heat shock protein Hsp90, N-terminal |
| InterPro | IPR036890 | Histidine kinase/HSP90-like ATPase superfamily |
| InterPro | IPR037196 | HSP90, C-terminal domain |
| PFam | PF00183 | Heat shock protein Hsp90 family |
| PFam | PF02518 | Histidine kinase/HSP90-like ATPase |
| Superfamily | SSF110942 | HSP90, C-terminal domain |
| Superfamily | SSF54211 | Ribosomal protein S5 domain 2-type fold |
| Superfamily | SSF55874 | Histidine kinase/HSP90-like ATPase superfamily |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 32 | 17 | 41 |
| disruptive | 2 | 16 | 17 | 55 |
| missense | 2 | 16 | 16 | 44 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 11 | 68 | 34 | 42 |
| disruptive | 11 | 55 | 46 | 141 |
| missense | 3 | 42 | 36 | 93 |
PlasmoDB Total SNPs: 134
Non-coding: 112 | Synonymous: 17 | Nonsynonymous: 5 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 21136929 | Food vacuole proteome of the malarial parasite Plasmodium falciparum. | Lamarque M, Tastet C, ..., Dubremetz JF | 10.1002/prca.200700112 |
| 24045696 | Proteomic analysis of detergent-resistant membrane microdomains in trophozoiteblood stage of the human malaria parasite Plasmodium falciparum. | Yam XY, Birago C, ..., Ponzi M | 10.1074/mcp.M113.029272 |
| 27128092 | Interrogating the Plasmodium Sporozoite Surface: Identification ofSurface-Exposed Proteins and Demonstration of Glycosylation on CSP and TRAP byMass Spectrometry-Based Proteomics. | Swearingen KE, Lindner SE, ..., Sinnis P | 10.1371/journal.ppat.1005606 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |