PF3D7_1222800

Genome location: Pf3D7_12_v3:919,948..922,798(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.02	0.99
Trophozoite	not expressed	0.08	0.95
Schizont	not expressed	0.02	0.99
Gametocyte	expressed	0.98	0.64

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1222800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.592 | MFS: -2.82 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5I7

"Best" AlphaFill ligand hit: TMO (trimethylamine oxide, Local RMSD=0.05) with 5WLQ (Global RMSD=3.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104732

Most Similar Human Ortholog: O60296

TM-align score: 0.40 | RMSD: 4.57

Seq Identity: 0.13 | Length: 141 / 263

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000115993	trafficking kinesin protein 2
ENSG00000182606	trafficking kinesin protein 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	11	8	16
disruptive	1	17	8	18
missense	1	16	7	15

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	20	9	16
disruptive	9	23	9	51
missense	6	17	9	44

PlasmoDB Total SNPs: 161

Non-coding: 151 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 263 | Molecular Weight (kDa): 31.256

UniProt ID(s): Q8I5I7

PDB ID(s): None

Isoelectric Point: 4.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A