PF3D7_1222900

Genome location: Pf3D7_12_v3:923,314..925,896(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.05	0.97
Trophozoite	expressed	0.42	0.75
Schizont	expressed	0.08	0.95
Gametocyte	expressed	0.47	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1222900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 5 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.238 | MFS: -3.259 | #Insertions: 0

PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1437800)

Relative Growth Rate: 0.43 ± 0.13
Confidence: 5.53

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1437800)

Modification: Disrupted | RMgm-3931

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5I6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533536

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	2	14	13	24
disruptive	15	47	30	72
missense	9	41	26	61

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	36	13	37
disruptive	24	100	48	108
missense	15	76	41	77

PlasmoDB Total SNPs: 79

Non-coding: 37 | Synonymous: 21 | Nonsynonymous: 21 | Stop Codon: 0

Protein Information

Protein Length: 501 | Molecular Weight (kDa): 60.281

UniProt ID(s): Q8I5I6

PDB ID(s): None

Isoelectric Point: 9.96

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A