About Gene List

PF3D7_1223000

Genome location: Pf3D7_12_v3:925,090..926,708(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.02 0.99
Trophozoite not expressed 0.11 0.93
Schizont possibly expressed 0.50 0.69
Gametocyte expressed 0.08 0.95

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1223000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.122 | MFS: -3.299 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5I5

"Best" AlphaFill ligand hit: AMP (adenosine monophosphate, Local RMSD=0.04) with 5O1U (Global RMSD=21.33)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532858

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 3 0 1
missense 0 0 0 0

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 0 0 0 0
disruptive 0 3 1 2
missense 0 0 0 0

PlasmoDB Total SNPs: 118

Non-coding: 114 | Synonymous: 1 | Nonsynonymous: 3 | Stop Codon: 0

Protein Information

Protein Length: 134 | Molecular Weight (kDa): 16.028

UniProt ID(s): Q8I5I5

PDB ID(s): None

Isoelectric Point: 4.46

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094