PF3D7_1223200

Genome location: Pf3D7_12_v3:932,071..934,404(+)

Genome classification: Core

Function and Localization

Product Description: nucleus export protein BRR6, putative

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005635	nuclear envelope
Process	GO:0006998	nuclear envelope organization

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.30	0.85
Trophozoite	not expressed	0.62	0.64
Schizont	possibly expressed	0.39	0.75
Gametocyte	not expressed	0.27	0.84

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1223200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.124 | MFS: -3.22 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5I4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109555

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	6	26	14	19
disruptive	4	21	13	49
missense	2	18	13	37

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	41	11	17
disruptive	8	55	27	83
missense	3	38	21	60

PlasmoDB Total SNPs: 109

Non-coding: 86 | Synonymous: 18 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 454 | Molecular Weight (kDa): 53.258

UniProt ID(s): Q8I5I4

PDB ID(s): None

Isoelectric Point: 9.34

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR018767	Brl1/Brr6 domain
InterPro	IPR040202	Nucleus export protein Brl1/Brr6
PFam	PF10104	Brl1/Brr6 domain
Superfamily	N/A	N/A