PF3D7_1223500

Genome location: Pf3D7_12_v3:946,864..961,465(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005887	integral component of plasma membrane
Function	GO:0038023	signaling receptor activity

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.59	0.73
Trophozoite	expressed	1.21	0.42
Schizont	expressed	0.83	0.60
Gametocyte	expressed	1.54	0.35

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1223500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.142 | MFS: -2.828 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1438400)

Modification: Other | RMgm-420

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: N/A

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532769

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	129	81	222
disruptive	122	369	216	607
missense	82	317	189	512

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	42	269	157	272
disruptive	226	870	420	969
missense	134	651	331	715

PlasmoDB Total SNPs: 443

Non-coding: 53 | Synonymous: 228 | Nonsynonymous: 162 | Stop Codon: 0

Protein Information

Protein Length: 4505 | Molecular Weight (kDa): 544.357

UniProt ID(s): A0A144A125

PDB ID(s): None

Isoelectric Point: 9.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR017241	Toll-like receptor
PFam	N/A	N/A
Superfamily	N/A	N/A