PF3D7_1223600

Genome location: Pf3D7_12_v3:962,262..968,275(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.43	0.74
Schizont	not expressed	0.18	0.89
Gametocyte	not expressed	0.50	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1223600

Resistome Missense Mutations: S332N, D566E

Resistome Compounds with Missense Mutations: AN13762, MMV982556

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.135 | MFS: -3.199 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8I5I1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533108

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	53	27	75
disruptive	31	176	88	256
missense	23	158	83	216

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	14	104	51	77
disruptive	77	399	207	442
missense	44	307	171	306

PlasmoDB Total SNPs: 212

Non-coding: 117 | Synonymous: 52 | Nonsynonymous: 42 | Stop Codon: 1

Protein Information

Protein Length: 1560 | Molecular Weight (kDa): 188.237

UniProt ID(s): A0A143ZZX1, Q8I5I1

PDB ID(s): None

Isoelectric Point: 8.12

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A