Product Description: vacuolar iron transporter
SignalP Peptide: N/A
# Transmembrane Domains: 5
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005783 | endoplasmic reticulum |
| Component | GO:0016020 | membrane |
| Function | GO:0015297 | antiporter activity |
| Function | GO:0015093 | ferrous iron transmembrane transporter activity |
| Function | GO:0005381 | iron ion transmembrane transporter activity |
| Function | GO:0005384 | manganese ion transmembrane transporter activity |
| Process | GO:0006879 | cellular iron ion homeostasis |
| Process | GO:0030026 | cellular manganese ion homeostasis |
| Process | GO:0006880 | intracellular sequestering of iron ion |
| Process | GO:0006826 | iron ion transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.11 | 0.95 |
| Trophozoite | expressed | 0.83 | 0.55 |
| Schizont | expressed | 0.14 | 0.91 |
| Gametocyte | expressed | 0.42 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1223700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.903 | MFS: -2.369 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1438600)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PY17X_1441100)
Modification: Disrupted | RMgm-4786
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5I0
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 11 | 3 | 7 |
| disruptive | 0 | 2 | 3 | 20 |
| missense | 0 | 2 | 3 | 10 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 13 | 10 | 12 |
| disruptive | 3 | 26 | 24 | 56 |
| missense | 0 | 13 | 21 | 37 |
PlasmoDB Total SNPs: 86
Non-coding: 84 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 273 | Molecular Weight (kDa): 30.984
UniProt ID(s): Q8I5I0
PDB ID(s): None
Isoelectric Point: 5.02
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR008217 | Ccc1 family |
| PFam | PF01988 | Ccc1 family |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 26786069 | A vacuolar iron-transporter homologue acts as a detoxifier in Plasmodium. | Slavic K, Krishna S, ..., Mota MM | 10.1038/ncomms10403 |
| 28198449 | Recombinant vacuolar iron transporter family homologue PfVIT from humanmalaria-causing Plasmodium falciparum is a Fe(2+)/H(+)exchanger. | Labarbuta P, Duckett K, ..., Law CJ | 10.1038/srep42850 |