Product Description: citrate/oxoglutarate carrier protein, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
Type | GO Term | Name |
---|---|---|
Component | GO:0005739 | mitochondrion |
Function | GO:0005371 | tricarboxylate secondary active transmembrane transporter activity |
Process | GO:0015742 | alpha-ketoglutarate transport |
Process | GO:0006843 | mitochondrial citrate transmembrane transport |
Process | GO:0006842 | tricarboxylic acid transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
Stage | LR class | MCA mean | MCA prop. zeros |
---|---|---|---|
Sporozoite | possibly expressed | N/A | N/A |
Ring | expressed | 0.19 | 0.90 |
Trophozoite | expressed | 0.22 | 0.86 |
Schizont | expressed | 0.04 | 0.97 |
Gametocyte | expressed | 0.27 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1223800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -0.31 | #Insertions: 4
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1438700)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1438700)
Modification: Disrupted | RMgm-3934
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5H9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 3 | 9 | 5 | 11 |
disruptive | 4 | 14 | 6 | 33 |
missense | 2 | 13 | 6 | 28 |
Any inclusion in genotype call
variant type | common | rare | doubleton | singleton |
---|---|---|---|---|
synonymous | 5 | 21 | 9 | 16 |
disruptive | 8 | 42 | 33 | 94 |
missense | 6 | 31 | 26 | 56 |
PlasmoDB Total SNPs: 40
Non-coding: 27 | Synonymous: 8 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 308 | Molecular Weight (kDa): 34.887
UniProt ID(s): Q8I5H9
PDB ID(s): None
Isoelectric Point: 9.89
Protein Domain Annotations:
Source | Family ID | Description |
---|---|---|
InterPro | IPR018108 | Mitochondrial substrate/solute carrier |
InterPro | IPR023395 | Mitochondrial carrier domain superfamily |
PFam | PF00153 | Mitochondrial substrate/solute carrier |
Superfamily | SSF103506 | Mitochondrial carrier domain superfamily |
PMID | Title | Authors | DOI/Link |
---|---|---|---|
12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
28784321 | Three mitochondrial transporters of Saccharomyces cerevisiae are essential forammonium fixation and lysine biosynthesis in synthetic minimal medium | Scarcia P, Palmieri L, ..., Rottensteiner H | 10.1016/j.ymgme.2017.07.004 |
20371607 | Identification and functional characterization of a novel mitochondrial carrierfor citrate and oxoglutarate in Saccharomyces cerevisiae | Castegna A, Scarcia P, ..., Palmieri F | 10.1074/jbc.M109.097188 |
34320205 | Utilization of ethanol for itaconic acid biosynthesis by engineered Saccharomycescerevisiae | Xu Y, Li Z | 10.1093/femsyr/foab043 |
38339147 | Ctp1 and Yhm2: Two Mitochondrial Citrate Transporters to Support MetabolicFlexibility of Saccharomyces cerevisiae | Assalve G, Lunetti P, Zara V, Ferramosca A | 10.3390/ijms25031870 |
9742088 | A novel DNA-binding protein bound to the mitochondrial inner membrane restoresthe null mutation of mitochondrial histone Abf2p in Saccharomyces cerevisiae | Cho JH, Ha SJ, ..., Chae CB | 10.1128/MCB.18.10.5712 |