Product Description: 50S ribosomal protein L24, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:1990904 | ribonucleoprotein complex |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0042254 | ribosome biogenesis |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.01 | 0.99 |
| Trophozoite | expressed | 0.11 | 0.93 |
| Schizont | expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.11 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1223900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.144 | MFS: -2.577 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1438800)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8I5H8
"Best" AlphaFill ligand hit: JK8 ((2~{r})-2-[[5-(2-chlorophenyl)-1,2-benzoxazol-3-yl]oxy]-2-phenyl-ethanamine, Local RMSD=1.10) with 6QX2 (Global RMSD=18.26)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101141
Most Similar Human Ortholog: X6RJ73
TM-align score: 0.61 | RMSD: 2.79
Seq Identity: 0.31 | Length: 121 / 227
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000143314 | mitochondrial ribosomal protein L24 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 6 | 4 | 8 |
| disruptive | 0 | 9 | 3 | 26 |
| missense | 0 | 9 | 3 | 21 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 14 | 5 | 11 |
| disruptive | 4 | 26 | 17 | 48 |
| missense | 1 | 20 | 16 | 31 |
PlasmoDB Total SNPs: 71
Non-coding: 63 | Synonymous: 7 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 227 | Molecular Weight (kDa): 26.791
UniProt ID(s): Q8I5H8
PDB ID(s): None
Isoelectric Point: 10.36
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003256 | Ribosomal protein L24 |
| InterPro | IPR005824 | KOW |
| InterPro | IPR008991 | Translation protein SH3-like domain superfamily |
| InterPro | IPR041988 | Ribosomal protein L26/L24, KOW domain |
| PFam | PF00467 | KOW |
| PFam | PF17136 | Ribosomal protein L24 |
| Superfamily | SSF50104 | Translation protein SH3-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |